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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Taurine, Temozolomide
Phytochemical Name Taurine (PubChem CID: 1123 )
Anticancer drug Name Temozolomide (PubChem CID: 5394 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 519
Pair Name Taurine, Temozolomide
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
In Vitro Model U-251MG Astrocytoma Homo sapiens (Human) CVCL_0021
Result The study showed that the combination between TMZ and TAU has a potential in anticancer properties against U-251 MG manifested by the induction of G2/M arrest and apoptosis. These results suggest that this combination may be useful to enhance the efficacy and reduce some adverse events of GBM treatment in the future.
03. Reference
No. Title Href
1 Synergistic Effects of Taurine and Temozolomide Via Cell Proliferation Inhibition and Apoptotic Induction on U-251 MG Human Glioblastoma Cells. Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4001-4009. doi: 10.31557/APJCP.2021.22.12.4001. Click
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