
| Pair Name | Taurine, Temozolomide | ||
| Phytochemical Name | Taurine (PubChem CID: 1123 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Taurine, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
| Result | The study showed that the combination between TMZ and TAU has a potential in anticancer properties against U-251 MG manifested by the induction of G2/M arrest and apoptosis. These results suggest that this combination may be useful to enhance the efficacy and reduce some adverse events of GBM treatment in the future. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic Effects of Taurine and Temozolomide Via Cell Proliferation Inhibition and Apoptotic Induction on U-251 MG Human Glioblastoma Cells. Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4001-4009. doi: 10.31557/APJCP.2021.22.12.4001. | Click |